Some might argue that without The Silence of the Lambs, Demme may not have made this list. Yes, he has made a surplus of outstanding films, including quite a few unjustly ignored documentaries such as The Agronomist (2003), but initially, the now 67-year-old director was most known more for his first two critical successes in the early 1980s ending up as box office duds (Handle With Care and Melvin and Howard). Despite the excellent Talking Heads doc Stop Making Sense (1984), the quirky masterpiece of Something Wild, and the Michelle Pfeiffer vehicle Married to the Mob (1988), Demme flew mostly under the radar for the rest of the Me Decade. That is, until he paired up with Anthony Hopkins, Jodie Foster, and screenwriter Ted Tally in 1991 to create the definitive portrait of a serial killer, the film that defined the psychological thriller/horror film hybrid for modern audiences.
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